We are interested in understanding the biogenesis of the archaeal cell envelope including processes like N-glycosylation, the assembly of macromolecular structures like pili and the archaellum, and regulatory processes depending on protein phosphorylation. We study these processes in two model archaea: the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius and the extremely halophilic euryarchaeon Haloferax volcanii.
We use genetic approaches to identify systems in Sulfolobus and Haloferax that are involved in the assembly of cell surface appendages and biochemically characterize the subunits and their interplay in the assembly process.
Frank Braun defends his PhD thesis about second messengers in Haloferax volcanii.
Closed this year with an online Christmas party and pub quizz !
As numbers were going down, more people were allowed back into the lab. Work discussions still held online only.
Getting used to the online format: Phillip Nußbaum defends succesfully his PhD thesis !
Two new Postdocs, Solenne Ithurbide and Alejandra Recalde, started in the lab. We wish them all the best !
First online PhD defense with Zhengqun Li! Congrats !
People were allowed back into the lab in shifts, from this point on, wearing masks was (is) mandatory.
Due to the rise of the Corona virus, the lab closed down for three month and we only held online meetings.
Our paper on the structure and function of FlaF and FlaG in archaellum assembly and function was published in Nature Microbiology.
We received two grants from the Volkswagen-Foundation: the "Momentum" grant to work on cell division in archaea and the Life? consortium to work on the evolution of vesicle trafficking from archaea to eukaryotes.
Sonja Albers was elected as an EMBO member. See press release here.
We showed the existence of c-di-AMP and discuss its possible function in Haloferax volcanii in Franks's article.
We congratulate Tessa Quax, who got an Emmy-Noether-Fellowship to start her own lab on halophilic viruses of archaea! See her lab webpage here.
Our review on mechanisms of archaeal biofilm formation was published in Nature Reviews Microbiology.
Our first "Halo" paper is out: Structure and function of the archaeal response regulator CheY in PNAS.
Archaea turned 40! Nature Microbiology and Nature Reviews MIcrobiology celebrate C. Woese and G. Fox seminal article in PNAS 1977:
At March 27-29th 2017 an international symposium will be organized by the Collaborative Research Centre 746 about "Coupling and Modification of Proteins. Information can be found here.
Kira Marakova's analysis of archaeal type IV pili is online at Frontiers in Microbiology.
Our DNA transport paper was mentioned in the current issue of Nature Reviews Microbiology in the briefs.
Our paper about the crenarchaeal DNA import system Ced is online in PNAS!
Our FlaH paper made the cover of Molecular Microbiology!
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